| Shift in V1/2 of activation | Shift in V1/2 of inactivation | Current
amplitude
@-30mV |
Recovery from Inactivation | I sus | Expression System | Reference |
|---|---|---|---|---|---|---|
| WT
-54±3.5 mv |
WT
-98±0.3 mv. |
WT
-260±49 pA/pF |
N.A. | N.A | Tsa-201 | Yang et al 2002 |
| LF
-59.2±5.5 mv |
LF
-94.4±0.3 mv |
LF
-272±54 pA/pF |
N.A. |
|
without beta1 | |
| N.S. | N.S. | N.S. |
N.S. : non different from WT ; N.A.: not available
COMMENTS ON IN VITRO DATA
For comments see L615E. See also KvLQT1-R583C
and HERG-R748W.