Nucleotide Change	Coding Effect		Mutation Type	Region	Phenotype	Reference
1631delC	P544+30X		Deletion/frameshift	C-term-CNBD	SND	Schulze-Bahr 2003
G1657A	D553N		Missense	C-term-CNBD	SND	Ueda K et al 2004

SND= Sinus Node Dysfunction

SCN5A
Since Sinus node dysfunction has been associated also with cardiac conduction defect and DCM phenotype see also

here; (Sequence references for SCN5A also included)

Nucleotide Change	Coding Effect		Mutation Type	Region	Phenotype	Reference
G481A	E161K(1)		Missense	DI/S2	SSS+CCB(1)	Smits et al. 2005
G1100A	R367H		Missense	DI/S5-S6	Atrial standstill(1)	Takehara et al, 2004
C3893T (m)*	P1298L (m)	and comments	Missense	DIII/S3	SSS	Benson et al. 2003
G4222A* (p)	G1408R (2) (p)			DIII/S5-S6
C4867T* (m)	R1623X (m)	and comments	Missense	DIV/S4	SSS	Benson et al. 2003
C659T* (p)	T220I (p)			DI/S4
4849–4851del (m)	delF1617(3) (m)	and comments	Missense	DIV/S3-S4	SSS	Benson et al. 2003
G4895A (p)	R1632H (4) (p)			DIV/S4

*All affected individuals were heterozygous carriers - each table row represents a proband with his/her two SCN5A mutations. SSS= Sick Sinus Syndrome (author's definition); OMIM reference: 163800.; m= maternally inherited; p = paternally inherited; CCD = Cardiac COnduction Defect

(1) Also causing Bugada syndrome ECG pattern
(2) Already reported in association with Brugada syndrome and conduction block and coded G1406R ( reference cDNA used by Benson et al. was not reported)
(3) Already reported as a LQTS mutation
(4) Codon 1623 is also affected in two distinct LQTS mutations.